The idea of antidotes is a controversial topic in homeopathy. In my practice, they are very very real, and I will present some clear cases to illustrate not only the correct remedy, but also the clear result from antidotes and how that is handled. I first learned about antidotes from George Vithoulkas and have experimented myself since to determine what truly antidotes in many cases and what does not. Of course, there are other interferences such as steroids, antidepressants, benzodiazepines, opioids, and others that affect outcomes from correct prescriptions even if they are not antidotes. Based on 49 years of Classical Homeopathy practice, I will offer my experience in how to manage these issues.